Porphyromonas gingivalis induces penetration of lipopolysaccharide and peptidoglycan through the gingival epithelium via degradation of junctional adhesion molecule 1
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چکیده
منابع مشابه
Peptidoglycan Induces the Production of Interleukin-8 via Calcium Signaling in Human Gingival Epithelium
The etiology of periodontal disease is multifactorial. Exogenous stimuli such as bacterial pathogens can interact with toll-like receptors to activate intracellular calcium signaling in gingival epithelium and other tissues. The triggering of calcium signaling induces the secretion of pro-inflammatory cytokines such as interleukin-8 as part of the inflammatory response; however, the exact mecha...
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چکیده ندارد.
15 صفحه اولCharacterization of Porphyromonas gingivalis-induced degradation of epithelial cell junctional complexes.
Porphyromonas gingivalis is considered among the etiological agents of human adult periodontitis. Although in vitro studies have shown that P. gingivalis has the ability to invade epithelial cell lines, its effect on the epithelial barrier junctions is not known. Immunofluorescence analysis of human gingival epithelial cells confirmed the presence of tight-junction (occludin), adherens junction...
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background: when provisional restorations are worn for long term period, the adhesion of bacteria becomes a primary factor in the development of periodontal diseases. the aims of this study were to evaluate the surface roughness and bacterial adhesion of four different provisional fixed prosthodontic materials. methods: ten cylindrical specimens were prepared from bis-acrylic composites (previs...
متن کاملAngiopoietin-like protein 2 regulates Porphyromonas gingivalis lipopolysaccharide-induced inflammatory response in human gingival epithelial cells
Angiopoietin-like protein 2 (ANGPTL2) maintains tissue homeostasis by inducing inflammation and angiogenesis. It is produced in infiltrating immune cells or resident cells, such as adipocytes, vascular endothelial cells, and tumor cells. We hypothesized that ANGPTL2 might play an important role as a unique mediator in both systemic and periodontal disease. We demonstrated an increased ANGPTL2 c...
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ژورنال
عنوان ژورنال: PLOS Pathogens
سال: 2019
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1008124